|
rs3077
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs3077
|
|
|
0.760 |
GeneticVariation |
BEFREE |
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B.
|
21346778 |
2011 |
|
rs3077
|
|
|
0.760 |
GeneticVariation |
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
rs3077
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance.
|
24846544 |
2014 |
|
rs3077
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |
|
rs3077
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population.
|
21408128 |
2011 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance.
|
24846544 |
2014 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population.
|
21408128 |
2011 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.
|
28613373 |
2017 |
|
rs9277535
|
|
|
0.760 |
GeneticVariation |
BEFREE |
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B.
|
21346778 |
2011 |
|
rs2856718
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Two recent genome-wide studies showed that the single-nucleotide polymorphisms in the HLA-DQ region (rs2856718 and rs9275572) were associated with chronic hepatitis B virus infection and chronic hepatitis C virus-associated hepatocellular carcinoma in Japanese patients.
|
24750255 |
2014 |
|
rs2856718
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs2856718
|
|
|
0.730 |
GeneticVariation |
BEFREE |
We aimed to determine impacts of HLA-DQ polymorphisms and their interactions with HBV mutations on the risks of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). rs2856718 (A>G) and rs9275319 (A>G) were genotyped in 1342 healthy controls, 327 HBV surface antigen (HBsAg) seroclearance subjects, 611 asymptomatic HBsAg carriers (ASCs), 1144 chronic hepatitis B (CHB) patients, 734 LC patients, and 1531 HCC patients using quantitative PCR.
|
25281206 |
2014 |
|
rs7453920
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs7453920
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.
|
28613373 |
2017 |
|
rs7549785
|
|
|
0.710 |
GeneticVariation |
BEFREE |
FCER1A (rs7549785) and possibly POLR3G (rs7712322) are shown to be associated with peginterferon alfa-2a response in adult patients with chronic hepatitis B.
|
30972912 |
2019 |
|
rs2296651
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B.
|
26642861 |
2016 |
|
rs2296651
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association of the S267F variant on NTCP gene and treatment response to pegylated interferon in patients with chronic hepatitis B: a multicentre study.
|
28635613 |
2018 |
|
rs2296651
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Intriguingly, ten individuals were identified as S267F homozygotes in population studies of chronic hepatitis B (CHB) patients.
|
30032030 |
2018 |
|
rs2296651
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The p.Ser267Phe NTCP variant is significantly associated with resistance to chronic hepatitis B and a lower incidence of acute-on-chronic liver failure.
|
25418280 |
2015 |
|
rs2296651
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In this study, we aimed to evaluate the prevalence of S267F polymorphism in Korean patients with chronic hepatitis B (CHB) and its association with disease progression and potential viral evolution in the preS1 domain of HBV.
|
29247233 |
2017 |
|
rs2296651
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The S267F variant may be a protective factor to resist chronic hepatitis B progression which showed a higher bile acid level in Chinese Han chronic HBV infection patients.
|
29205714 |
2018 |
|
rs12979860
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We aimed to investigate whether IFNL3 polymorphism (rs12979860) influences the long-term response of chronic hepatitis B (CHB) treatment to conventional IFN.
|
24118626 |
2014 |