|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
PSYGENET |
We found that a single nucleotide polymorphism in the CAMK4 promoter was significantly associated with cocaine addiction, whereas variations in the CREB promoter regions did not correlate with drug abuse.
|
19001277 |
2008 |
|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
CTD_human |
Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement.
|
16359811 |
2006 |
|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
CTD_human |
Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse.
|
11717377 |
2001 |
|
Cocaine Dependence
|
0.510 |
GeneticVariation
|
disease |
BEFREE |
To test the relevance of these observations for addiction in humans, we performed an association study of CAMK4 and CREB promoter polymorphisms with cocaine addiction in a large sample of addicts.
|
19001277 |
2008 |
|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
CTD_human |
Evidence for beta1-adrenergic receptor involvement in amygdalar corticotropin-releasing factor gene expression: implications for cocaine withdrawal.
|
18596687 |
2009 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms that span CREB1 were associated with treatment-emergent suicidality among men with depression, extending an observation of association with male anger expression in a prior independent cohort.
|
17548750 |
2007 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression.
|
23619509 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
One hundred-ninety MD patients collected in the context of a resistant depression study and treated with antidepressants for at least 4weeks were genotyped for 5 CREB1 SNPs (rs2709376, rs2253206, rs7569963, rs7594560, and rs4675690).
|
20643483 |
2011 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in depression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206.
|
21215389 |
2011 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
CREB regulates thousands of genes, yet to date, only a handful that mediate depression or antidepressant response have been identified as relevant CREB targets.
|
31255680 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
|
29722134 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Findings regarding the CREB gene support REM sleep's role in depression.
|
18221628 |
2007 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the two CREB1 DNA variants previously identified as linked to depression as well as three additional polymorphisms spanning the gene.
|
15999345 |
2005 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men.
|
19548263 |
2010 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Viral vector-mediated inhibition of one of the CREB-target genes regulated by chr-ECS, Fzd6, produced anxiety and depressive-like effects in behavioral models of depression.
|
21937024 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression.
|
23619509 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions.
|
29197324 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In the NEWMOOD cohort polymorphisms of the genes of the serotonin transporter, 5-HT1A, 5-HT1B and 5-HT2A and endocannabinoid CB1 receptors, tryptophan hydroxylase, CREB1, BDNF and GIRK provide evidence for the involvement of these genes in the development of depression.
|
23269207 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
G protein-activated K+ channel 2 (GIRK2) and cAMP-response element binding protein (CREB1) are involved in synaptic plasticity and their genes have been implicated depression and memory processing.
|
20943350 |
2011 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
CREB regulates thousands of genes, yet to date, only a handful that mediate depression or antidepressant response have been identified as relevant CREB targets.
|
31255680 |
2019 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression.
|
12457397 |
2002 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
One hundred-ninety MD patients collected in the context of a resistant depression study and treated with antidepressants for at least 4weeks were genotyped for 5 CREB1 SNPs (rs2709376, rs2253206, rs7569963, rs7594560, and rs4675690).
|
20643483 |
2011 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Findings regarding the CREB gene support REM sleep's role in depression.
|
18221628 |
2007 |