|
Septicemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, decreased AT1R expression inactivated the MAPK signaling pathway (shown as decreased extracellular signal-regulated kinase and cyclic adenosine 3',5'-monophosphate response element binding protein expression), decreased EF, heart rate, and concentrations of TnT, cTnI, and CK-MB, but increased sepsis rat survival rate.
|
31433522 |
2020 |
|
Post-Traumatic Stress Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
We discovered that the modified single prolonged stress-exposure induced significant PTSD-like symptoms as well as mildly impaired hippocampal Cornu Ammonis 1 (CA1) subregion cytoarchitecture, but not dentate gyrus neurogenesis, together with a gradual inhibition of TrkA-CREB-ERK signalings in hippocampal CA1 subregion.
|
31704315 |
2020 |
|
Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, decreased AT1R expression inactivated the MAPK signaling pathway (shown as decreased extracellular signal-regulated kinase and cyclic adenosine 3',5'-monophosphate response element binding protein expression), decreased EF, heart rate, and concentrations of TnT, cTnI, and CK-MB, but increased sepsis rat survival rate.
|
31433522 |
2020 |
|
Brain Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In conclusion, CBL ameliorated cerebral ischemia injury through reducing neuroinflammation partly <i>via</i> the activation of CREB/PGC-1α pathway and may play a therapeutic role as anti-neuroinflammatory agents in the brain disorders associated with neuroinflammation.
|
31695614 |
2019 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present results suggested that miR‑101 may serve a role in colon cancer by directly targeting CREB1.
|
30816471 |
2019 |
|
Dysmenorrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Ginsenoside Rf alleviates dysmenorrhea and inflammation through the BDNF-TrkB-CREB pathway in a rat model of endometriosis.
|
30547177 |
2019 |
|
Glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of lipocalin 2 (LCN2), monoamine oxidase A (MAOA), hemoglobin subunit β (HBB), paired box 6 (PAX6), fibronectin (FN1) and cAMP responsive element binding protein 1 (CREB1) were demonstrated to be involved in the pathogenesis of glaucoma.
|
31115504 |
2019 |
|
Hay fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
CPEB4 and CREB might be implicated in the pathogenesis of SAR.
|
30616374 |
2019 |
|
Kidney Failure, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, decreased expressions of hippocampal CaMKIIα, p-CaMKIIα (Thr286), CREB1, p-CREB1 (Ser133), and BDNF were observed in the hippocampus of CRF mice, but YGY extract significantly restored these protein expressions.
|
31055001 |
2019 |
|
Mycosis Fungoides
|
0.010 |
AlteredExpression
|
group |
BEFREE |
There was downregulation of the expression of phosphatase and tensin homolog (PTEN) and CREB1, known targets of miR-17~92 members; higher gene expression of interleukin-2 and interferon-γ; and a statistically lower average percentage of GATA3<sup>+</sup> dermal cells (6·7% vs. 42·3%), were detected in unilesional MF compared with early MF.
|
30431147 |
2019 |
|
Osteoporosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Dual-luciferase assay and biotin pull-down assay demonstrate that osteoporosis GWAS lead SNPs rs34920465-G and rs6426749-C alleles can respectively bind transcription factors JUN::FOS and CREB1, and upregulate ZBTB40 and ZBTB40-IT1 expression.
|
30661131 |
2019 |
|
Gambling, Pathological
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This behavioural change appears superficially similar to the iatrogenic gambling disorder (GD) observed in a sub-set of patients with Parkinson's disease (PD), and has been associated with increased activation of the intra-cellular signalling proteins GSK3β and CREB in the striatum.
|
30019362 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that RBM10 reduces the phosphorylation of CREB via the AKT signalling pathway, suggesting that RBM10 exhibits its effect on lung adenocarcinoma cell proliferation via the RAP1/AKT/CREB signalling pathway.
|
30955253 |
2019 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings establish that targeting IL1β-NFKB/CREB-Wnt signalling should be considered for adjuvant therapy to prevent breast cancer bone metastasis.
|
31676788 |
2019 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
A549 cells selected in vivo to give brain metastases exhibited cisplatin resistance and decreased expression of phosphorylated CREB1.
|
30093630 |
2019 |
|
Caffeine related disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, caffeine (200 μM) at a dose twice higher than the clinically relevant dose (36-130 μM) had minor or no effects on several basic neuronal functions, such as neurite outgrowth, synapse formation, expression of A<sub>1</sub>R and transcription of CREB-1 and c-Fos, further supporting the safety of caffeine for clinical use.
|
30822423 |
2019 |
|
Metastatic non-small cell lung cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer.
|
30093630 |
2019 |
|
Iron Overload
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, it disturbed the iron homeostasis through increasing C/EBP homologous protein (CHOP), decreasing phosphorylated cAMP responsive element binding protein(P-CREB) and hepcidin levels leading to significant serum and hepatic iron overload.
|
31499193 |
2019 |
|
Osteoarthritis, Knee
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis.
|
31182934 |
2019 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present results suggested that miR‑101 may serve a role in colon cancer by directly targeting CREB1.
|
30816471 |
2019 |
|
Tauopathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, using a transgenic mouse model and primary cell cultures along with quantitative PCR, immunoblotting, and immunohistochemistry, we tested whether the UPR is induced in <i>in vivo</i> and <i>in vitro</i> murine models of tauopathy that are based on expression of mutant tau<sup>P301L</sup> We found no evidence for the UPR in the rTg4510 mouse model, in which mutant tau is transgenically expressed under the control of tetracycline-controlled transactivator protein.
|
31053641 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vivo, participation of Nox1, CREB, and Gremlin1, as well as CREB:CRE binding was corroborated in a rat PAH model.
|
30802716 |
2019 |
|
Memory dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although the underlying signaling mechanism for impairment of memory function following induction of ER stress remains elusive, recent studies have highlighted that inactivation of a transcription factor, CREB, which is essential for synaptic function and memory formation, plays an essential role for ER stress-induced synaptic and memory dysfunction.
|
30477403 |
2019 |
|
metastatic intraocular melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Infectious Knockdown of CREB and HIF-1 for the Treatment of Metastatic Uveal Melanoma.
|
31357444 |
2019 |
|
Adrenal gland hypofunction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with healthy controls, 19 of the 68 genes were found modulated in patients with AI at baseline, 18 of which were restored to control levels 12 weeks after therapy was switched: ARNTL [BMAL] (P = 0.024), CLOCK (P = 0.016), AANAT (P = 0.021), CREB1 (P = 0.010), CREB3 (P = 0.037), MAT2A (P = 0.013); PRKAR1A, PRKAR2A, and PRKCB (all P < 0.010) and PER3, TIMELESS, CAMK2D, MAPK1, SP1, WEE1, CSNK1A1, ONP3, and PRF1 (all P < 0.001).
|
29846607 |
2018 |