|
Abnormal involuntary movement
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, the antidyskinetic effects of KD5040 on pathological movements triggered by <sub>l</sub> -dopa were investigated by testing abnormal involuntary movements (AIMs) and measuring the activations of FosB, cAMP-dependent phosphor protein of 32 kDa (DARPP-32), extracellular signal-regulated kinases (ERK), and cAMP response element-binding (CREB) protein in the striatum.
|
28424060 |
2017 |
|
Abnormal involuntary movement
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Although this mechanism underlying the beneficial effect of Riluzole on AIMs needs to be confirmed, it provides clues towards novel or existing compounds for the treatment of AIMs that modulate the activity of CREB1 and, hence, its downstream targets.
|
30484112 |
2019 |
|
Absence of sensation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Results The escape latency and swimming distance were greater, and the number of crossings of the platform location and time spent in the platform quadrant were less in the Sev group compared with the control group. cAMP, PKA, CREB, and p-CREB protein expression was downregulated in the Sev group 1 day after anaesthesia compared with the control group.
|
29332488 |
2018 |
|
Acrodysostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the cells from an acrodysostosis patient showed low cAMP accumulation, which resulted in a decrease in the phosphorylated cAMP Response Element-Binding Protein (pCREB)/CREB ratio.
|
25064455 |
2014 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia.
|
26008971 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The protection of both NB4 cells and APL blasts was associated with (inactivating) phosphorylation of PKA site Ser118 of pro-apoptotic Bad and (activating) phosphorylation of PKA site Ser133 of the AML oncogene CREB.
|
23449452 |
2013 |
|
Acute Undifferentiated Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation.
|
20541704 |
2010 |
|
Addictive Behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
The study is the first report on the identification of a role of CREB1 gene polymorphism with addiction.
|
24704376 |
2014 |
|
Addictive Behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
To test the relevance of these observations for addiction in humans, we performed an association study of CAMK4 and CREB promoter polymorphisms with cocaine addiction in a large sample of addicts.
|
19001277 |
2008 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas.
|
22539488 |
2012 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that RBM10 reduces the phosphorylation of CREB via the AKT signalling pathway, suggesting that RBM10 exhibits its effect on lung adenocarcinoma cell proliferation via the RAP1/AKT/CREB signalling pathway.
|
30955253 |
2019 |
|
Adenocarcinoma, Clear Cell
|
0.020 |
Biomarker
|
disease |
BEFREE |
EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have now been consistently described in 5 histopathologically and behaviorally diverse neoplasms: angiomatoid fibrous histiocytoma, conventional clear cell sarcoma (of tendons and aponeuroses), clear cell sarcoma-like tumor of the gastrointestinal tract, hyalinizing clear cell carcinoma of the salivary gland, and primary pulmonary myxoid sarcoma.
|
22510762 |
2012 |
|
Adenocarcinoma, Clear Cell
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein (CREB) family (ATF1 and CREB1) have been reported in a diverse group of tumors including angiomatoid fibrous histiocytoma (AFH), soft tissue and gastrointestinal clear cell sarcoma, primary pulmonary myxoid sarcoma, and hyalinizing clear cell carcinoma of salivary gland.
|
28009602 |
2017 |
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Three nuclear transcriptional factors, AP-1, CREB, and Pit-1, which are targets of protein kinase C and A, appear to play critical roles in both neoplastic growth and hormone secretion in hormone-producing adenomas.
|
10728913 |
1999 |
|
Adrenal cortical hypofunction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with healthy controls, 19 of the 68 genes were found modulated in patients with AI at baseline, 18 of which were restored to control levels 12 weeks after therapy was switched: ARNTL [BMAL] (P = 0.024), CLOCK (P = 0.016), AANAT (P = 0.021), CREB1 (P = 0.010), CREB3 (P = 0.037), MAT2A (P = 0.013); PRKAR1A, PRKAR2A, and PRKCB (all P < 0.010) and PER3, TIMELESS, CAMK2D, MAPK1, SP1, WEE1, CSNK1A1, ONP3, and PRF1 (all P < 0.001).
|
29846607 |
2018 |
|
Adrenal gland hypofunction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with healthy controls, 19 of the 68 genes were found modulated in patients with AI at baseline, 18 of which were restored to control levels 12 weeks after therapy was switched: ARNTL [BMAL] (P = 0.024), CLOCK (P = 0.016), AANAT (P = 0.021), CREB1 (P = 0.010), CREB3 (P = 0.037), MAT2A (P = 0.013); PRKAR1A, PRKAR2A, and PRKCB (all P < 0.010) and PER3, TIMELESS, CAMK2D, MAPK1, SP1, WEE1, CSNK1A1, ONP3, and PRF1 (all P < 0.001).
|
29846607 |
2018 |
|
Adult Clear Cell Sarcoma of Soft Parts
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
One CCSST case (6.3%) was found to have EWSR1 and CREM rearrangements, and 4 of 6 CCSLGT cases (66.7%) had EWSR1 rearrangement, of which 2 (33.3%) showed ATF1 rearrangement and the other 2 cases (33.3%) showed CREB1 rearrangement.
|
30219084 |
2018 |
|
Adult Clear Cell Sarcoma of Soft Parts
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, EWSR1-CREB1 was identified in a clear cell sarcoma of soft tissue providing further evidence that this chimeric variant is not exclusive to gastrointestinal clear cell sarcomas and should be included in RT-PCR assays of soft tissue clear cell sarcomas.
|
19561568 |
2009 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results show that CREB1 can be considered a biomarker to stratify patients for anti-TGFβ treatments and a therapeutic target in glioblastoma.
|
25084773 |
2014 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma.Cancer Discov.10, 1230-1241 (2014).
|
30190576 |
2018 |
|
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Either overexpressed CREB, or antisense destruction of AChE-R mRNA, PKC, or protein kinase A (PKA) inhibitors-but not CREB combined with PKC inhibition suppressed-this proliferation, suggesting that CREB's repression of this process involves a PKC-mediated pathway, whereas impaired CREB regulation allows AChE-R-induced, PKA-mediated proliferation of glioblastoma tumors.
|
15153340 |
2004 |
|
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In contrast, antagonizing the NMDAR or the Ca<sup>2+</sup>-dependent transcription factor CREB impaired DSB-repair similarly and resulted in a radiosensitizing effect in LN229 and U-87MG cells, indicating a common link between NMDAR signaling and CREB activity in glioblastoma.
|
30970642 |
2019 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer.
|
29799025 |
2018 |
|
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer.
|
20423907 |
2010 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes.
|
26004186 |
2015 |