|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Somatic mutation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Histiocytoma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.070 |
Biomarker
|
disease |
BEFREE |
The Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1) is required for protein expression from the HIV-1 RNAs which contain a binding site for the Rev protein, termed the Rev-responsive element (RRE).
|
1501291 |
1992 |
|
Infection by human herpesvirus 6
|
0.010 |
Biomarker
|
disease |
BEFREE |
HHV-6 infection in the presence of Tat resulted in significantly higher LTR activation than that observed by Tat or HHV-6 alone, indicating that HHV-6 and Tat interact synergically.
|
1657039 |
1991 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Following in vitro immunization of naive human B lymphocytes with reverse-transcriptase (RT) or HIV transactivator protein (tat), messenger RNA (mRNA) would be isolated from these cells.
|
1695989 |
1990 |
|
Leukoplakia, Hairy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.
|
1851858 |
1991 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This knowledge may prove valuable in molecular analysis of translocations occurring in this region and in exploring the possibility of a role for the CREB1 locus in malignancy.
|
2142119 |
1990 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This knowledge may prove valuable in molecular analysis of translocations occurring in this region and in exploring the possibility of a role for the CREB1 locus in malignancy.
|
2142119 |
1990 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.070 |
Biomarker
|
disease |
BEFREE |
The art/trs transactivator protein of human immunodeficiency virus (HIV) was expressed in mammalian cells as a 19-kilodalton protein that was immunoreactive with sera from HIV-infected patients.
|
3033827 |
1987 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.070 |
Biomarker
|
disease |
BEFREE |
The hypusine-containing protein eukaryotic initiation factor 5A (eIF-5A) is a cellular cofactor critically required for the function of the Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1). eIF-5A localizes in the nuclear and cytoplasmic compartments of mammalian cells, suggesting possible activities on the level of regulated mRNA transport and/or protein translation.
|
7971969 |
1994 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Sequence requirements of ATF2 and CREB binding to the human T-cell leukemia virus type 1 LTR R region.
|
8610463 |
1996 |
|
Lymphoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas.
|
8798441 |
1996 |
|
Keratoconus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In view of the alteration in gene expression for multiple proteins, five common transcription factors, AP1, AP2, CREB, Sp1, and NF-kappa B were examined for their possible roles in keratoconus.
|
9196072 |
1997 |
|
Neoplasm Metastasis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, the cell-surface adhesion molecule MCAM/MUC18 that is involved in metastasis of human melanoma was downregulated in the KCREB-transfected cells.
|
9366524 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells.
|
9366524 |
1997 |
|
melanoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
In addition, the cell-surface adhesion molecule MCAM/MUC18 that is involved in metastasis of human melanoma was downregulated in the KCREB-transfected cells.
|
9366524 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The HTLV-1 transactivator protein, Tax, is believed to be crucial for the development of the disease since it is transforming in vitro and induces tumors in transgenic animals.
|
9420268 |
1998 |
|
Respiratory distress
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In contrast to the CREBalpha delta mice, CREB null mice are smaller than their littermates and die immediately after birth from respiratory distress.
|
9539763 |
1998 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain.
|
10077326 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It is thought that CREB1 is not expressed in tumor fibroblasts because the Western blot analysis using anti-CREB1 antibody was not able to detect CREB1 in the nuclear protein extract from these cells.
|
10545204 |
1999 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia.
|
10570922 |
1999 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia.
|
10570922 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Three nuclear transcriptional factors, AP-1, CREB, and Pit-1, which are targets of protein kinase C and A, appear to play critical roles in both neoplastic growth and hormone secretion in hormone-producing adenomas.
|
10728913 |
1999 |
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Three nuclear transcriptional factors, AP-1, CREB, and Pit-1, which are targets of protein kinase C and A, appear to play critical roles in both neoplastic growth and hormone secretion in hormone-producing adenomas.
|
10728913 |
1999 |