Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.510 GeneticVariation disease BEFREE To test the relevance of these observations for addiction in humans, we performed an association study of CAMK4 and CREB promoter polymorphisms with cocaine addiction in a large sample of addicts. 19001277 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE Polymorphisms that span CREB1 were associated with treatment-emergent suicidality among men with depression, extending an observation of association with male anger expression in a prior independent cohort. 17548750 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression. 23619509 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in depression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206. 21215389 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling. 29722134 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE We genotyped the two CREB1 DNA variants previously identified as linked to depression as well as three additional polymorphisms spanning the gene. 15999345 2005
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men. 19548263 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. 12457397 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in depression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206. 21215389 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling. 29722134 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE Polymorphisms that span CREB1 were associated with treatment-emergent suicidality among men with depression, extending an observation of association with male anger expression in a prior independent cohort. 17548750 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE We genotyped the two CREB1 DNA variants previously identified as linked to depression as well as three additional polymorphisms spanning the gene. 15999345 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE Sequence variations in CREB1 cosegregate with depressive disorders in women. 12851637 2003
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE Genetic linkage of region containing the CREB1 gene to depressive disorders in families with recurrent, early-onset, major depression: a re-analysis and confirmation of sex-specific effect. 19517574 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression. 23619509 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men. 19548263 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. 17300755 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD. 28225778 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants. 20643483 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder. 22386572 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE This work also predicted that the genes with the greatest impact on model stability were those involved in the neurotrophin pathway, such as CREB, BDNF (which has been associated with major depressive disorder in a variety of studies) and TRkB, followed by genes and metabolites related to 5-HT synthesis. 24093582 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression. 23844928 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment-emergent suicidality in men with major depressive disorder, but its functional effects have not been studied. 18678793 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE The results continue to support sex-specific linkage of the CREB1 region to mood disorders among women from families with RE-MDD. 19517574 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. 12457397 2002