Cocaine Dependence
|
0.510 |
GeneticVariation
|
disease |
BEFREE |
To test the relevance of these observations for addiction in humans, we performed an association study of CAMK4 and CREB promoter polymorphisms with cocaine addiction in a large sample of addicts.
|
19001277 |
2008 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms that span CREB1 were associated with treatment-emergent suicidality among men with depression, extending an observation of association with male anger expression in a prior independent cohort.
|
17548750 |
2007 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression.
|
23619509 |
2013 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in depression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206.
|
21215389 |
2011 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
CREB regulates thousands of genes, yet to date, only a handful that mediate depression or antidepressant response have been identified as relevant CREB targets.
|
31255680 |
2019 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
|
29722134 |
2018 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Findings regarding the CREB gene support REM sleep's role in depression.
|
18221628 |
2007 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the two CREB1 DNA variants previously identified as linked to depression as well as three additional polymorphisms spanning the gene.
|
15999345 |
2005 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men.
|
19548263 |
2010 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions.
|
29197324 |
2017 |
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
G protein-activated K+ channel 2 (GIRK2) and cAMP-response element binding protein (CREB1) are involved in synaptic plasticity and their genes have been implicated depression and memory processing.
|
20943350 |
2011 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
CREB regulates thousands of genes, yet to date, only a handful that mediate depression or antidepressant response have been identified as relevant CREB targets.
|
31255680 |
2019 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression.
|
12457397 |
2002 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Findings regarding the CREB gene support REM sleep's role in depression.
|
18221628 |
2007 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions.
|
29197324 |
2017 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
G protein-activated K+ channel 2 (GIRK2) and cAMP-response element binding protein (CREB1) are involved in synaptic plasticity and their genes have been implicated depression and memory processing.
|
20943350 |
2011 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in depression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206.
|
21215389 |
2011 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Previous studies identified a rare, highly penetrant A(-115)G transition within the human CREB1 promoter that reduced promoter activity in vitro and was associated with depressive disorders in RE-MDD families.
|
21598377 |
2011 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
|
29722134 |
2018 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms that span CREB1 were associated with treatment-emergent suicidality among men with depression, extending an observation of association with male anger expression in a prior independent cohort.
|
17548750 |
2007 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the two CREB1 DNA variants previously identified as linked to depression as well as three additional polymorphisms spanning the gene.
|
15999345 |
2005 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sequence variations in CREB1 cosegregate with depressive disorders in women.
|
12851637 |
2003 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage of region containing the CREB1 gene to depressive disorders in families with recurrent, early-onset, major depression: a re-analysis and confirmation of sex-specific effect.
|
19517574 |
2010 |