|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
GermlineCausalMutation
|
disease |
ORPHANET |
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
|
22561515 |
2012 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
GREM1 and POLE variants in hereditary colorectal cancer syndromes.
|
26493165 |
2016 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein.
|
16545136 |
2006 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
|
22561515 |
2012 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
GREM1 germline mutation screening in Ashkenazi Jewish patients with familial colorectal cancer.
|
25992589 |
2015 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.
|
12696020 |
2003 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
GeneticVariation
|
disease |
BEFREE |
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
|
18084292 |
2008 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients.
|
21128281 |
2011 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors.
|
17881565 |
2007 |
|
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
|
0.610 |
Biomarker
|
disease |
CLINGEN |
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
|
25419707 |
2015 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hence, these experiments demonstrated that GREM1 is involved in CRC development and procession and provide a new idea for CRC diagnosis, resistance therapy, and prognosis.
|
30426548 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
|
24737748 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In total, 44% of CRCs were positive for stromal GREM1, which was associated with decreased lymphovascular invasion, a lower cancer stage, and nuclear β-catenin staining.
|
28041973 |
2017 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, low-frequency UTR variant rs12915554 in the gene GREM1 was in relation to CRC susceptibility in a Chinese population and this variation might promote CRC development through enhancing GREM1 expression in a miRNA-mediated posttranscriptional manner.
|
28977865 |
2017 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The intestine-specific transcription factor CDX2 and Wnt effector TCF7L2 bound near rs16969681, with significantly higher affinity for the risk allele, and CDX2 overexpression in CDX2/GREM1-negative cells caused re-expression of GREM1. rs16969681 influences CRC risk through effects on Wnt-driven GREM1 expression in colorectal tumors.
|
25131200 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Most of the approximately 13 high-penetrance genes that predispose to CRC primarily predispose to colorectal polyps, and each gene is associated with a specific type of polyp, whether conventional adenomas (APC, MUTYH, POLE, POLD1, NTHL1), juvenile polyps (SMAD4, BMPR1A), Peutz-Jeghers hamartomas (LKB1/STK11) and mixed polyps of serrated and juvenile types (GREM1).
|
26169059 |
2015 |
|
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
On this basis, our findings suggest that CRAC1 is unlikely to be implicated in the development of colorectal cancer in general or, if involved, it is through small somatic mutations or other loss of function mechanisms rather than allele loss.
|
12885466 |
2003 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer.
|
24586997 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
|
24737748 |
2014 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Near GREM1, we found using fine-mapping that the previously-identified association between tagSNP rs4779584 and CRC actually resulted from two independent signals represented by rs16969681 (P = 5.33×10(-8)) and rs11632715 (P = 2.30×10(-10)).
|
21655089 |
2011 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion a high penetrant duplication in the regulatory region of GREM1, predisposing to CRC, was identified in a family with attenuated/atypical polyposis.
|
26493165 |
2016 |
|
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
|
25990418 |
2015 |