|
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gremlin-1 potentiates the dedifferentiation of VSMC in early stages of atherosclerosis.
|
31494396 |
2020 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against 5 TAAs (HMGB3, ZWINT, GREM1, NUSAP1 and MMP12) might have favorable diagnostic values in LC detection, and autoantibody against HMGB3 has the potential to serve as a serological biomarker in early-stage LC.
|
31629809 |
2020 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against 5 TAAs (HMGB3, ZWINT, GREM1, NUSAP1 and MMP12) might have favorable diagnostic values in LC detection, and autoantibody against HMGB3 has the potential to serve as a serological biomarker in early-stage LC.
|
31629809 |
2020 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Autoantibodies against 5 TAAs (HMGB3, ZWINT, GREM1, NUSAP1 and MMP12) might have favorable diagnostic values in LC detection, and autoantibody against HMGB3 has the potential to serve as a serological biomarker in early-stage LC.
|
31629809 |
2020 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Older adult controls (OACs) and people with Alzheimer's disease (AD) were asked to solve 9 verbal proportional analogies, 3 of which had been primed by Deese/Roediger-McDermott lists where the critical lure (and problem solution) was presented as a word in the list (true memory), 3 of which were primed by DRM lists whose critical lures were spontaneously activated during list presentation (false memory), and 3 of which were unprimed.
|
31208282 |
2019 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we study axon and dendrite contact guidance and neuronal morphological features of wild-type, AS, and UBE3A-overexpressing neurons (Dup15q autism model) on micrograting substrates, with the aim to clarify the role of UBE3A in neuronal guidance.
|
31798818 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression analysis of clinical breast cancer datasets revealed that high expression of GREM1 in breast cancer stroma is correlated with a poor prognosis regardless of the molecular subtype.
|
31533776 |
2019 |
|
Intracranial Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The effects of TAM-derived exosomal miR-155-5p on IA formation and TAM activation and infiltration by regulation of GREM1 in vivo were measured in IA rats injected with exosomes or those from TAMs transfected with miR-155-5p inhibitor.
|
31657855 |
2019 |
|
Colonic Polyps
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
This finding supports comprehensive testing of the GREM1 regulatory region in families of all ethnicities with multiple colon polyps or colon cancer, and when Lynch syndrome is suspected.
|
29804199 |
2019 |
|
Osteitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We suggest DRM and GOSS as complementary methods for capturing, classifying and quantifying time-dependent changes in GPA-related osteitis.
|
30717680 |
2019 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study was carried out to characterize the expression and function of GREM1 in osteosarcoma cells, thus extending our understanding of osteosarcoma metastasis.
|
31525341 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> Our data suggest that Gremlin 1 may be the key regulator in the pathogenesis of PCOS.
|
30712421 |
2019 |
|
Schizophrenia, Childhood
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Negative regulators of the bone morphogenetic protein (BMP) pathway were upregulated in SCZ GPCs, including BAMBI, FST, and GREM1, whose overexpression retained SCZ GPCs at the progenitor stage.
|
31242417 |
2019 |
|
Proliferative vitreoretinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Gremlin-1 may serve as a novel target to treat proliferative vitreoretinopathy (PVR) and inhibit subretinal fibrosis, which is a risk factor for influencing the therapeutic effects of anti-vascular endothelial growth factor (anti-VEGF) on neovascular age-related macular degeneration (nAMD).
|
31700227 |
2019 |
|
Exudative age-related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, Gremlin-1 may serve as a novel target to treat proliferative vitreoretinopathy (PVR) and inhibit subretinal fibrosis, which is a risk factor for influencing the therapeutic effects of anti-vascular endothelial growth factor (anti-VEGF) on neovascular age-related macular degeneration (nAMD).
|
31700227 |
2019 |
|
Osteosarcoma of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study was carried out to characterize the expression and function of GREM1 in osteosarcoma cells, thus extending our understanding of osteosarcoma metastasis.
|
31525341 |
2019 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression analysis of clinical breast cancer datasets revealed that high expression of GREM1 in breast cancer stroma is correlated with a poor prognosis regardless of the molecular subtype.
|
31533776 |
2019 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study was carried out to characterize the expression and function of GREM1 in osteosarcoma cells, thus extending our understanding of osteosarcoma metastasis.
|
31525341 |
2019 |
|
Hereditary Nonpolyposis Colorectal Cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein we report a novel 24 kb tandem duplication of the 5' regulatory region of GREM1 in a patient without Ashkenazi Jewish heritage, who had a family history that was concerning for Lynch syndrome and satisfied Amsterdam II criteria.
|
29804199 |
2019 |
|
Granulomatosis with polyangiitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We suggest DRM and GOSS as complementary methods for capturing, classifying and quantifying time-dependent changes in GPA-related osteitis.
|
30717680 |
2019 |
|
Metacarpal synostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, C-L syndrome-like phenotypes as well as other syndactyly disorders with or without metacarpal synostosis/phalangeal disorganization are also known to be associated with specific LRP4 mutations, adenomatous polyposis coli (APC) truncating mutations, genomic rearrangements of the GREM1-FMN1 locus, as well as FMN1 mutations.
|
30569497 |
2019 |
|
Lynch Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein we report a novel 24 kb tandem duplication of the 5' regulatory region of GREM1 in a patient without Ashkenazi Jewish heritage, who had a family history that was concerning for Lynch syndrome and satisfied Amsterdam II criteria.
|
29804199 |
2019 |
|
estrogen receptor-negative breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results show that GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients.
|
31694641 |
2019 |
|
Rectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Outcomes analyzed were number of clear Distal Resection Margins (DRM or DM), complete Circumferential Resection Margins (CRM) and complete, nearly complete and incomplete Total Mesorectal Excision (TME) and of patients who received laparoscopic or open treatment for rectal cancer.
|
30300377 |
2018 |
|
Cleft upper lip
|
0.010 |
Biomarker
|
disease |
BEFREE |
Novel GREM1 Variations in Sub-Saharan African Patients With Cleft Lip and/or Cleft Palate.
|
29489415 |
2018 |