GREM1, gremlin 1, DAN family BMP antagonist, 26585

N. diseases: 179; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease GENOMICS_ENGLAND
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease GENOMICS_ENGLAND
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.130 Biomarker disease HPO
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.110 Biomarker disease HPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.100 Biomarker disease HPO
CUI: C0018932
Disease: Hematochezia
Hematochezia 		0.100 Biomarker phenotype HPO
CUI: C0021933
Disease: Intussusception
Intussusception 		0.100 Biomarker disease HPO
CUI: C0034887
Disease: Rectal polyp
Rectal polyp 		0.100 Biomarker disease HPO
CUI: C0079218
Disease: Fibromatosis, Aggressive
Fibromatosis, Aggressive 		0.100 Biomarker disease HPO
CUI: C0278804
Disease: Adenocarcinoma of duodenum
Adenocarcinoma of duodenum 		0.100 Biomarker disease HPO
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.100 Biomarker disease HPO
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker disease HPO
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.100 Biomarker disease HPO
CUI: C0949059
Disease: Polyp of large intestine
Polyp of large intestine 		0.100 Biomarker disease HPO
CUI: C1868071
Disease: Adenomatous colonic polyposis
Adenomatous colonic polyposis 		0.100 Biomarker phenotype HPO
CUI: C4023006
Disease: Juvenile colonic polyposis
Juvenile colonic polyposis 		0.100 Biomarker disease HPO
CUI: C4023010
Disease: Hyperplastic colonic polyposis
Hyperplastic colonic polyposis 		0.100 Biomarker disease HPO
CUI: C0010678
Disease: Cysticercosis
Cysticercosis 		0.010 GeneticVariation disease BEFREE Preliminary immunogenicity studies employing the radiolabeled R-Tso18 protein in immune co-precipitation assays indicated sero-positivity for T. saginata-infected calf sera (6/13), T. solium cysticercosis human (7/22) and pig (2/2) sera and E. multilocularis (6/10)- and E. granulosus (1/12)-infected human sera, whereas other helminth-infection sera were negative. 9610644 1998
CUI: C0018889
Disease: Helminthiasis
Helminthiasis 		0.010 Biomarker disease BEFREE Preliminary immunogenicity studies employing the radiolabeled R-Tso18 protein in immune co-precipitation assays indicated sero-positivity for T. saginata-infected calf sera (6/13), T. solium cysticercosis human (7/22) and pig (2/2) sera and E. multilocularis (6/10)- and E. granulosus (1/12)-infected human sera, whereas other helminth-infection sera were negative. 9610644 1998
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.130 Biomarker disease BEFREE Using genetic linkage analysis, supplemented by allele loss in tumors, we have provided evidence for a new colorectal cancer susceptibility gene, CRAC1 (colorectal adenoma and carcinoma), mapping to chromosome 15q14-q22. 10092300 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Interestingly, we detected DRM expression in normal cells obtained from several patients, but not in tumor cell lines established from the same patients. 10894942 2000
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.090 Biomarker phenotype BEFREE The data suggest that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis. 10894942 2000
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.030 AlteredExpression phenotype BEFREE The data suggest that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis. 10894942 2000
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.320 GeneticVariation disease BEFREE Wnt pathway abnormalities (APC mutation/LOH, beta-catenin mutation/nuclear expression) occurred in 11 SAs, including 6/31 (19%) non-FAP tumours.CRAC1 LOH occurred in 23% of tumours. 12117880 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Wnt pathway abnormalities (APC mutation/LOH, beta-catenin mutation/nuclear expression) occurred in 11 SAs, including 6/31 (19%) non-FAP tumours.CRAC1 LOH occurred in 23% of tumours. 12117880 2002