GREM1, gremlin 1, DAN family BMP antagonist, 26585

N. diseases: 179; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease GENOMICS_ENGLAND
CUI: C1832587
Disease: POLYPOSIS SYNDROME, HEREDITARY MIXED, 1
POLYPOSIS SYNDROME, HEREDITARY MIXED, 1 		0.610 Biomarker disease GENOMICS_ENGLAND
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.130 Biomarker disease HPO
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.110 Biomarker disease HPO
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.100 Biomarker disease HPO
CUI: C0018932
Disease: Hematochezia
Hematochezia 		0.100 Biomarker phenotype HPO
CUI: C0021933
Disease: Intussusception
Intussusception 		0.100 Biomarker disease HPO
CUI: C0034887
Disease: Rectal polyp
Rectal polyp 		0.100 Biomarker disease HPO
CUI: C0079218
Disease: Fibromatosis, Aggressive
Fibromatosis, Aggressive 		0.100 Biomarker disease HPO
CUI: C0278804
Disease: Adenocarcinoma of duodenum
Adenocarcinoma of duodenum 		0.100 Biomarker disease HPO
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.100 Biomarker disease HPO
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.100 Biomarker disease HPO
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.100 Biomarker disease HPO
CUI: C0949059
Disease: Polyp of large intestine
Polyp of large intestine 		0.100 Biomarker disease HPO
CUI: C1868071
Disease: Adenomatous colonic polyposis
Adenomatous colonic polyposis 		0.100 Biomarker phenotype HPO
CUI: C4023006
Disease: Juvenile colonic polyposis
Juvenile colonic polyposis 		0.100 Biomarker disease HPO
CUI: C4023010
Disease: Hyperplastic colonic polyposis
Hyperplastic colonic polyposis 		0.100 Biomarker disease HPO
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.010 Biomarker disease BEFREE <b>Conclusion:</b> Our data suggest that Gremlin 1 may be the key regulator in the pathogenesis of PCOS. 30712421 2019
CUI: C0795858
Disease: Chromosome 15q, trisomy
Chromosome 15q, trisomy 		0.020 GeneticVariation disease BEFREE Duplication 15q syndrome (Dup15q) is an autism-associated disorder co-incident with high rates of pediatric epilepsy. 28888970 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE GREM1 region iii methylation was associated with increased tumor size (P = 0.02), stage (P = 0.013), grade (P = 0.04), tumor (P = 0.001), and endothelial cell (P = 0.0001) proliferation and decreased mean vessel density (P = 0.001) in a hospital-based ccRCC series (n = 150). 20042676 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.030 Biomarker disease BEFREE GREM1, a member of the differential screening-selected gene aberrative in neuroblastoma (DAN) family of genes known for its highly regulated expression pattern during folliculogenesis and a downstream effecter of oocyte-derived growth and differentiation factor 9, was down-regulated 3-fold (-3.08) in women with DOR versus control; down-regulation was confirmed by qRT-PCR (-4.02). 22160428 2012
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.030 Biomarker disease BEFREE GREM1, a member of the differential screening-selected gene aberrative in neuroblastoma (DAN) family of genes known for its highly regulated expression pattern during folliculogenesis and a downstream effecter of oocyte-derived growth and differentiation factor 9, was down-regulated 3-fold (-3.08) in women with DOR versus control; down-regulation was confirmed by qRT-PCR (-4.02). 22160428 2012
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.030 Biomarker disease BEFREE GREM1, a member of the differential screening-selected gene aberrative in neuroblastoma (DAN) family of genes known for its highly regulated expression pattern during folliculogenesis and a downstream effecter of oocyte-derived growth and differentiation factor 9, was down-regulated 3-fold (-3.08) in women with DOR versus control; down-regulation was confirmed by qRT-PCR (-4.02). 22160428 2012
CUI: C3839507
Disease: Diminished ovarian reserve
Diminished ovarian reserve 		0.010 AlteredExpression disease BEFREE GREM1, a member of the differential screening-selected gene aberrative in neuroblastoma (DAN) family of genes known for its highly regulated expression pattern during folliculogenesis and a downstream effecter of oocyte-derived growth and differentiation factor 9, was down-regulated 3-fold (-3.08) in women with DOR versus control; down-regulation was confirmed by qRT-PCR (-4.02). 22160428 2012
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.050 AlteredExpression disease BEFREE GREM1, FRZB and DKK1 mRNA expression were strongly decreased in osteoarthritis. 24286177 2013