|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers of the IL10 T allele (rs1554286) and the IL20 T allele (rs1400986) conferred protection from psoriasis [odds ratio (OR) = 0·63, corrected P-value (Pc) = 0·007; OR = 0·62, Pc = 0·038, respectively].
|
28150860 |
2017 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elucidation of this interaction provides a better understanding of cytokine cross-talk in RA and a rationale for more effective biologic therapies that target IL-20R2 instead of individual cytokines from IL-20 family.
|
27619991 |
2016 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is involved in the development of skin psoriasis.
|
26176762 |
2015 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence indicates that IL-20's interaction with its receptors might have proinflammatory effects on chronic inflammatory diseases, particularly rheumatoid arthritis (RA), osteoporosis, and breast cancer.
|
24816455 |
2014 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present review, we focus on IL-7, IL-18, IL-32 and IL-10 family of cytokines (IL-19, IL-20 and IL-22) as they are implicated in contributing to the pathogenesis of RA, which could be targeted and offer new therapeutic options for RA therapy.
|
24437572 |
2014 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our previous study, a single-nucleotide polymorphism (SNP) of IL-20-1723CG (rs1713239) was found to be associated with psoriasis progression, especially in those induced by upper respiratory tract infection.
|
23892591 |
2014 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 19 (IL-19), IL-20 and IL-24 signal through type I and type II IL-20 receptors and are associated with inflammatory skin diseases such as psoriasis and atopic dermatitis.
|
23793061 |
2013 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between the IL-20-1723C→G allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population.
|
21109726 |
2011 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is a proinflammatory cytokine of the IL-10 family that is involved in psoriasis, rheumatoid arthritis, atherosclerosis, and stroke.
|
21844205 |
2011 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and IL-22 mRNA levels were also upregulated in RA SFMCs but their level of expression was lower than that of IL-10 or IL-19.
|
20001767 |
2010 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20, an IL-10 family member, is involved in various inflammatory diseases, such as psoriasis, rheumatoid arthritis, and atherosclerosis.
|
19342680 |
2009 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study suggests that different cytokines are players in the psoriasis pathogenesis although only the IL-10 family members IL-22 and IL-20 directly cause the characteristic epidermal alterations.
|
19330474 |
2009 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes.
|
19731362 |
2009 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
|
19830738 |
2009 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients.
|
18061474 |
2008 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is involved in inflammatory diseases such as psoriasis, atherosclerosis, and rheumatoid arthritis, etc.
|
18758357 |
2008 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is involved in inflammatory diseases such as psoriasis, atherosclerosis, and rheumatoid arthritis, etc.
|
18758357 |
2008 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study we tested the hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and investigated single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients (n=254) and healthy controls (n=224).
|
18480827 |
2008 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP).
|
17263806 |
2007 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and its receptors were detected in RA synovial fibroblasts (RASFs), using immunohistochemical staining.
|
16947773 |
2006 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data indicate that IL-20 may be an important effector cytokine in psoriasis, and that its inhibition may represent a potential therapeutic target.
|
16645593 |
2006 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
During treatment with calcipotriol or CsA, IL-19 and IL-20 mRNA levels decrease in accordance with the clinical improvement of psoriasis.
|
16225599 |
2005 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, family-based studies are required to confirm the impact of IL-19, IL-20 and IL-24 genes in the genetic predisposition for psoriasis.
|
15889129 |
2005 |