DLG5, discs large MAGUK scaffold protein 5, 9231

N. diseases: 36; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE We assess the frequency of the CARD15 SNPs and of the R30Q mutation in DLG5 and their contribution to the development of CD in a cohort of unrelated IBD patients (151 CD, 325 ulcerative colitis (UC)) and healthy controls (236) from South-east Norway (IBSEN cohort). 16493449 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease LHGDN Polymorphisms 3020insC in CARD15 and SNP rs2165047 in DLG5 were associated with specific phenotypes in this pediatric-onset CD cohort. 17476680 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE DLG5 variants contribute to Crohn disease risk in a Canadian population. 16450402 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease LHGDN Further investigation of the observed TRD may contribute towards enlightening the role of DLG5 in physiological processes influencing transmission of chromosomes to the surviving offspring, which, in turn, may help in understanding its implication in the development of CD among men. 16446977 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease LHGDN Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric onset of CD. 17451203 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE Furthermore, we evaluated whether DLG5 variants alter gastrointestinal permeability in Crohn's disease (CD). 16494592 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE We assess the frequency of the CARD15 SNPs and of the R30Q mutation in DLG5 and their contribution to the development of CD in a cohort of unrelated IBD patients (151 CD, 325 ulcerative colitis (UC)) and healthy controls (236) from South-east Norway (IBSEN cohort). 16493449 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 Biomarker disease BEFREE DLG5 and OCTN do not play a role in the susceptibility to IBD, CD, or ulcerative colitis in the Flemish population but play a role in the phenotypic expression of the disease. 16344053 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE We have now examined the association of the R30Q polymorphism in a large cohort of British IBD cases, tested for interaction between the DLG5 and CARD15 genes and assessed possible association of DLG5 with clinical features of Crohn's disease (CD) and ulcerative colitis (UC). 16944184 2007
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Recently, Stoll and colleagues reported a novel finding of genetic variation in the DLG5 gene that is associated with IBD (CD and UC combined). 15841097 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE No significant association of DLG5 polymorphisms with CD or UC was observed. 15955786 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Six DLG5 variants (p.R30Q, p.P1371Q, p.G1066G, rs2289308, DLG_e26, p.D1507D) were genotyped in two study populations: (1) German IBD patients (CD n = 250; ulcerative colitis (UC) n = 150) and German healthy controls (n = 422); (2) Hungarian IBD patients (CD n = 144; UC n = 124) and Hungarian healthy controls (n = 205). 16494592 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 Biomarker disease BEFREE No associations between DLG5 and UC were observed. 15843420 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE In this study we genotyped a cohort of 402 Canadian CD and 179 ulcerative colitis (UC) patients and 537 healthy controls for three IBD/CD-associated DLG5 variants. 16450402 2006
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE Taken together, our data indicate that down-regulated DLG5 expression increases the stemness of breast cancer cells by enhancing TAZ expression, contributing to TAM resistance in breast cancer. 30450766 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE In summary, loss of DLG5 expression promoted breast cancer malignancy by inactivating the Hippo signaling pathway and increasing nuclear YAP. 28169360 2017
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.020 Biomarker disease LHGDN Association of DLG5 variants with gluten-sensitive enteropathy. 18559397 2008
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.020 GeneticVariation disease BEFREE Our study does not support the effect of the R30Q DLG5 variant in CeD or IBD predisposition in the Spanish population. 20796250 2011
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.020 GeneticVariation disease BEFREE DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease. 16670524 2006
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.020 GeneticVariation disease BEFREE We studied the incidence of DLG5 alleles in a population of IBD patients from Pennsylvania. 20037206 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE In summary, loss of DLG5 expression promoted breast cancer malignancy by inactivating the Hippo signaling pathway and increasing nuclear YAP. 28169360 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE Taken together, our data indicate that down-regulated DLG5 expression increases the stemness of breast cancer cells by enhancing TAZ expression, contributing to TAM resistance in breast cancer. 30450766 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.020 AlteredExpression disease BEFREE Lower Dlg5 expression was associated with advanced stages of HCC, and poor overall and disease-free survival of HCC patients. 28390157 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.020 Biomarker disease BEFREE The effect of Dlg5 on HCC tumor growth in vivo was studied in a tumor xenograft model in mice. 31787846 2019
CUI: C2931133
Disease: Pediatric Crohn's disease
Pediatric Crohn's disease 		0.020 GeneticVariation disease BEFREE Polymorphisms 3020insC in CARD15 and SNP rs2165047 in DLG5 were associated with specific phenotypes in this pediatric-onset CD cohort. 17476680 2007