Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 GeneticVariation LHGDN The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders. 16026766

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 GeneticVariation LHGDN Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. 18256540

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 GeneticVariation LHGDN Thus in human melanoma PH domain mutations of PKB/Akt do not play a major role in melanoma carcinogenesis. 11828257

2002
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.400 GeneticVariation LHGDN A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. 16142341

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN An activating mutation in AKT1 in human prostate cancer. 18798258

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.100 GeneticVariation LHGDN Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients. 19132987

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.100 GeneticVariation LHGDN KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway. 17546049

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.070 GeneticVariation LHGDN Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas. 18172656

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 GeneticVariation LHGDN Akt is altered in an animal model of Huntington's disease and in patients. 15845076

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia. 15522255

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet. 17383860

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects. 16987250

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker LHGDN AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. 17616691

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker LHGDN Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways. 16820947

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 Biomarker LHGDN The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. 18400376

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 Biomarker LHGDN Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. 18974133

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker LHGDN The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. 12727836

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker LHGDN Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. 18829502

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction. 17469127

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. 17148458

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells. 17584963

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. 16820098

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. 15467757

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 16543232

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3KAkt. 17898861

2007