×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Schizophrenia
0.900
Biomarker
LHGDN
Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia .
15522255
2004
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Schizophrenia
0.900
Biomarker
LHGDN
Convergent evidence for impaired AKT1 -GSK3beta signaling in schizophrenia .Nat.Genet.
17383860
2007
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Schizophrenia
0.900
Biomarker
LHGDN
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
16987250
2006
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Schizophrenia
0.900
GeneticVariation
LHGDN
The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders .
16026766
2005
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
ovarian neoplasm
0.700
AlteredExpression
LHGDN
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
19067848
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Lung Neoplasms
0.500
AlteredExpression
LHGDN
CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways.
19073147
2009
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Lung Neoplasms
0.500
PosttranslationalModification
LHGDN
The potential role of Akt phosphorylation in human cancers.
18409144
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Lung Neoplasms
0.500
Biomarker
LHGDN
AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway.
17616691
2007
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Lung Neoplasms
0.500
AlteredExpression
LHGDN
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
18644989
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Lung Neoplasms
0.500
GeneticVariation
LHGDN
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
18256540
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Lung Neoplasms
0.500
AlteredExpression
LHGDN
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha.
15802268
2005
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Lung Neoplasms
0.500
Biomarker
LHGDN
Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways.
16820947
2006
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
melanoma
0.500
AlteredExpression
LHGDN
Lack of cytoplasmic ERK activation is an independent adverse prognostic factor in primary cutaneous melanoma.
18509361
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
melanoma
0.500
Biomarker
LHGDN
The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway.
18400376
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
melanoma
0.500
Biomarker
LHGDN
Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment.
18974133
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
melanoma
0.500
GeneticVariation
LHGDN
Thus in human melanoma PH domain mutations of PKB /Akt do not play a major role in melanoma carcinogenesis.
11828257
2002
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Squamous cell carcinoma
0.400
AlteredExpression
LHGDN
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
15217935
2004
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Squamous cell carcinoma
0.400
Biomarker
LHGDN
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
12727836
2003
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Squamous cell carcinoma
0.400
Biomarker
LHGDN
Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.
18829502
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Osteosarcoma
0.400
GeneticVariation
LHGDN
A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8.
16142341
2005
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Prostatic Neoplasms
0.400
GeneticVariation
LHGDN
An activating mutation in AKT1 in human prostate cancer.
18798258
2008
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Prostatic Neoplasms
0.400
Biomarker
LHGDN
Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction.
17469127
2007
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Prostatic Neoplasms
0.400
Biomarker
LHGDN
Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer.
17148458
2007
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Prostatic Neoplasms
0.400
Biomarker
LHGDN
Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells.
17584963
2007
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Prostatic Neoplasms
0.400
Biomarker
LHGDN
Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract.
16820098
2006