Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet. 17383860

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects. 16987250

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 GeneticVariation LHGDN The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders. 16026766

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia. 15522255

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 AlteredExpression LHGDN Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer. 19067848

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression LHGDN CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways. 19073147

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 PosttranslationalModification LHGDN The potential role of Akt phosphorylation in human cancers. 18409144

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression LHGDN Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. 18644989

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 GeneticVariation LHGDN Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. 18256540

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 AlteredExpression LHGDN Lack of cytoplasmic ERK activation is an independent adverse prognostic factor in primary cutaneous melanoma. 18509361

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 Biomarker LHGDN The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. 18400376

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 Biomarker LHGDN Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. 18974133

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker LHGDN AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. 17616691

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker LHGDN Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways. 16820947

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression LHGDN Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. 15802268

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 GeneticVariation LHGDN Thus in human melanoma PH domain mutations of PKB/Akt do not play a major role in melanoma carcinogenesis. 11828257

2002
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. 18924134

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. 19116269

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker LHGDN Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. 18829502

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN An activating mutation in AKT1 in human prostate cancer. 18798258

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins. 18512729

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival. 18776922

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer. 18519679

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. 18625725

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. 18184439

2008