Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0002448
Disease: Ameloblastoma
Ameloblastoma 		0.010 AlteredExpression LHGDN Immunohistochemical analysis of aberrant signaling in the PI3K/AKT/mTOR pathway in ameloblastomas may represent a valuable tool for elucidating pathogenesis, aggressiveness and selecting optimal therapeutics. 18826385

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004135
Disease: Ataxia Telangiectasia
Ataxia Telangiectasia 		0.010 AlteredExpression LHGDN AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. 18413665

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036095
Disease: Salivary Gland Neoplasms
Salivary Gland Neoplasms 		0.010 Biomarker LHGDN Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. 18355439

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0042138
Disease: Uterine Neoplasms
Uterine Neoplasms 		0.010 Biomarker LHGDN Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. 18071906

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0011875
Disease: Diabetic Angiopathies
Diabetic Angiopathies 		0.010 Biomarker LHGDN R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. 17566113

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0027149
Disease: Myxoma
Myxoma 		0.010 AlteredExpression LHGDN M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. 17151107

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0333641
Disease: Atrophic
Atrophic 		0.010 Biomarker LHGDN Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. 16916907

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.010 Biomarker LHGDN The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10. 15385469

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0003130
Disease: Anoxia
Anoxia 		0.020 Biomarker LHGDN NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. 18924134

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C3714514
Disease: Infection
Infection 		0.020 PosttranslationalModification LHGDN Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation. 18782353

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C3714514
Disease: Infection
Infection 		0.020 Biomarker LHGDN Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. 19029952

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0008479
Disease: Chondrosarcoma
Chondrosarcoma 		0.020 Biomarker LHGDN BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway. 18720410

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0334634
Disease: Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 		0.020 Biomarker LHGDN Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. 18339899

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0003130
Disease: Anoxia
Anoxia 		0.020 Biomarker LHGDN Thus, PKB/Akt may regulate specific cellular responses to growth factors such as insulin under adverse conditions such as hypoxia. 17544543

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0007124
Disease: Noninfiltrating Intraductal Carcinoma
Noninfiltrating Intraductal Carcinoma 		0.030 AlteredExpression LHGDN Immunoexpression of HER family, neuregulin, MAPK and AKT in invasive ductal carcinomas of the breast. 18714568

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 Biomarker LHGDN Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. 18323784

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.030 AlteredExpression LHGDN Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. 17924977

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1176475
Disease: Ductal Carcinoma
Ductal Carcinoma 		0.030 PosttranslationalModification LHGDN Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression. 17549359

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.030 AlteredExpression LHGDN PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma. 16012720

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.030 AlteredExpression LHGDN Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. 12888921

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.030 PosttranslationalModification LHGDN We demonstrated higher protein levels of the PI3K subunit p110 in neutrophils from MDS patients and found that though the fMLP-induced phosphorylation of PKB/Akt and ERK1/2 could also be enhanced by pretreatment with GM-CSF in these patients, the degree and kinetics of PKB/Akt and ERK1/2 phosphorylation were significantly disturbed. 12529294

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0001430
Disease: Adenoma
Adenoma 		0.040 AlteredExpression LHGDN Active AKT and mTOR, were present in all adenomas, carcinomas, and in normal colorectal mucosa. 18351386

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.040 AlteredExpression LHGDN Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment. 17977950

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 GeneticVariation LHGDN Akt is altered in an animal model of Huntington's disease and in patients. 15845076

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.050 Biomarker LHGDN BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer. 17960583

2007