Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.100 AlteredExpression LHGDN Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. 15102693

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.100 PosttranslationalModification LHGDN CXCR4 expression is associated with pelvic lymph node metastasis in cervical adenocarcinoma. 17504381

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0001430
Disease: Adenoma
Adenoma 		0.040 AlteredExpression LHGDN Active AKT and mTOR, were present in all adenomas, carcinomas, and in normal colorectal mucosa. 18351386

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0002448
Disease: Ameloblastoma
Ameloblastoma 		0.010 AlteredExpression LHGDN Immunohistochemical analysis of aberrant signaling in the PI3K/AKT/mTOR pathway in ameloblastomas may represent a valuable tool for elucidating pathogenesis, aggressiveness and selecting optimal therapeutics. 18826385

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0003130
Disease: Anoxia
Anoxia 		0.020 Biomarker LHGDN NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. 18924134

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0003130
Disease: Anoxia
Anoxia 		0.020 Biomarker LHGDN Thus, PKB/Akt may regulate specific cellular responses to growth factors such as insulin under adverse conditions such as hypoxia. 17544543

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.100 Biomarker LHGDN Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas. 18550470

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004135
Disease: Ataxia Telangiectasia
Ataxia Telangiectasia 		0.010 AlteredExpression LHGDN AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. 18413665

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker LHGDN Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3. 18458087

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0333641
Disease: Atrophic
Atrophic 		0.010 Biomarker LHGDN Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. 16916907

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.100 AlteredExpression LHGDN High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma. 17375124

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.010 Biomarker LHGDN The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10. 15385469

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.070 GeneticVariation LHGDN Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas. 18172656

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0006413
Disease: Burkitt Lymphoma
Burkitt Lymphoma 		0.080 AlteredExpression LHGDN Functional role of phosphatidylinositol 3-kinase/Akt pathway on cell growth and lytic cycle of Epstein-Barr virus in the Burkitt's lymphoma cell line, P3HR-1. 16732486

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.100 AlteredExpression LHGDN Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. 17461449

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0008479
Disease: Chondrosarcoma
Chondrosarcoma 		0.020 Biomarker LHGDN BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway. 18720410

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 AlteredExpression LHGDN Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. 17478078

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 Biomarker LHGDN Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells. 18451140

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 PosttranslationalModification LHGDN CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation. 17599831

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.060 Biomarker LHGDN The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. 16912864

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.350 AlteredExpression LHGDN Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. 15888491

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.350 AlteredExpression LHGDN Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues. 16202996

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.350 AlteredExpression LHGDN X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. 16278380

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0011875
Disease: Diabetic Angiopathies
Diabetic Angiopathies 		0.010 Biomarker LHGDN R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. 17566113

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1176475
Disease: Ductal Carcinoma
Ductal Carcinoma 		0.030 PosttranslationalModification LHGDN Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression. 17549359

2007