Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0025202
Disease: melanoma
melanoma 		0.500 GeneticVariation LHGDN Thus in human melanoma PH domain mutations of PKB/Akt do not play a major role in melanoma carcinogenesis. 11828257

2002
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.100 Biomarker LHGDN Immunohistochemical localization of phosphorylated AKT in multiple myeloma. 11902142

2002
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. 12244302

2002
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 PosttranslationalModification LHGDN Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. 12244303

2002
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.030 PosttranslationalModification LHGDN We demonstrated higher protein levels of the PI3K subunit p110 in neutrophils from MDS patients and found that though the fMLP-induced phosphorylation of PKB/Akt and ERK1/2 could also be enhanced by pretreatment with GM-CSF in these patients, the degree and kinetics of PKB/Akt and ERK1/2 phosphorylation were significantly disturbed. 12529294

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0023418
Disease: leukemia
leukemia 		0.100 AlteredExpression LHGDN The scope of this paper was to investigate whether a HL60 human leukemia cell clone (named AR) with constitutively active Akt1 was resistant to TRAIL. 12592338

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker LHGDN The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. 12727836

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.030 AlteredExpression LHGDN Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. 12888921

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer. 14520710

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN HER2/neu uses Akt to suppress retinoic acid response element binding activity in MDA-MB-453 breast cancer cells. 14612949

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.100 AlteredExpression LHGDN In vitro studies using human thyroid cancer cells demonstrated that nuclear translocation of Akt 1 and pAkt were associated with cytoplasmic p27 and cell invasion and migration. 14985374

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 AlteredExpression LHGDN Thus a physiological concentration of insulin stimulated Akt-1 and Akt-2 phosphorylation in human skeletal muscle in the absence of hyperglycemia, but Akt-2 expression and stimulation appeared to be impaired in muscle of obese patients with atypical diabetes presenting with severe hyperglycemia. 15010337

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.100 AlteredExpression LHGDN Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. 15102693

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 AlteredExpression LHGDN Our data suggest that AKT is involved in endothelium dysfunction in hypertension. 15136501

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 AlteredExpression LHGDN Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. 15217935

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.010 Biomarker LHGDN The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10. 15385469

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. 15467757

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. 15475446

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia. 15522255

2004
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Regulated association of protein kinase B/Akt with breast tumor kinase. 15539407

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.050 Biomarker LHGDN GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. 15609321

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.350 Biomarker LHGDN AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type. 15710591

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 AlteredExpression LHGDN Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. 15802268

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. 15806160

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 GeneticVariation LHGDN Akt is altered in an animal model of Huntington's disease and in patients. 15845076

2005