Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.350 Biomarker LHGDN AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type. 15710591

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.900 Biomarker LHGDN A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects. 16987250

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.400 GeneticVariation LHGDN A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. 16142341

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation. 17935714

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.070 GeneticVariation LHGDN Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas. 18172656

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.100 GeneticVariation LHGDN Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients. 19132987

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1176475
Disease: Ductal Carcinoma
Ductal Carcinoma 		0.030 PosttranslationalModification LHGDN Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression. 17549359

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 GeneticVariation LHGDN Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. 18256540

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 16543232

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. 17551921

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0001430
Disease: Adenoma
Adenoma 		0.040 AlteredExpression LHGDN Active AKT and mTOR, were present in all adenomas, carcinomas, and in normal colorectal mucosa. 18351386

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C3714514
Disease: Infection
Infection 		0.020 Biomarker LHGDN Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway. 19029952

2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.030 AlteredExpression LHGDN Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. 12888921

2003
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0042138
Disease: Uterine Neoplasms
Uterine Neoplasms 		0.010 Biomarker LHGDN Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. 18071906

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 Biomarker LHGDN Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. 18323784

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.100 Biomarker LHGDN Akt down-regulation with isoform-specific siRNA constructs or with an Akt1/2-specific pharmacologic inhibitor strongly induced apoptosis in approximately half of the primary MM samples analyzed. 18635812

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004135
Disease: Ataxia Telangiectasia
Ataxia Telangiectasia 		0.010 AlteredExpression LHGDN AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. 18413665

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.040 GeneticVariation LHGDN Akt is altered in an animal model of Huntington's disease and in patients. 15845076

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. 15806160

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker LHGDN Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3. 18458087

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. 16951146

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0333641
Disease: Atrophic
Atrophic 		0.010 Biomarker LHGDN Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. 16916907

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. 16820098

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.500 Biomarker LHGDN AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. 17616691

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation LHGDN An activating mutation in AKT1 in human prostate cancer. 18798258

2008