|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders.
|
12851637 |
2003 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, these results have been supported by a host of additional published findings that implicate sequence variations in CREB1 in the sex-dependent development of syndromic mood disorders, as well as related clinical features and disorders.
|
19517574 |
2010 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders.
|
12851637 |
2003 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association study of CREB1 and childhood-onset mood disorders.
|
15999345 |
2005 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The effects of CREB1 promoter variants on promoter activity, their influence on the development of mood disorders and related clinical features, and the interaction of their phenotypic expression with sex seem likely to be complex and allele-specific rather than a general property of the CREB1 locus.© 2010 Wiley-Liss, Inc.
|
20957653 |
2010 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiomatoid fibrous histiocytoma (AFH) is a rarely metastasizing neoplasm that typically occurs in the deep dermis and subcutis of the extremities of young patients, characterized by a t(2;22) translocation involving EWSR1 and CREB1.
|
31652145 |
2019 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiomatoid fibrous histiocytoma: pleomorphic variant associated with multiplication of EWSR1-CREB1 fusion gene.
|
22038502 |
2012 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that has been associated with EWSR1-CREB1 gene fusion.
|
29932283 |
2018 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To review the current status of AFH, discussing putative etiology, histopathology with variant morphology and differential diagnosis, and current genetics, including overlap with other tumors harboring EWSR1-CREB1 and EWSR1-ATF1 fusions.
|
25927151 |
2015 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity?
|
28281318 |
2018 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment-emergent suicidality in men with major depressive disorder, but its functional effects have not been studied.
|
18678793 |
2008 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This work also predicted that the genes with the greatest impact on model stability were those involved in the neurotrophin pathway, such as CREB, BDNF (which has been associated with major depressive disorder in a variety of studies) and TRkB, followed by genes and metabolites related to 5-HT synthesis.
|
24093582 |
2013 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results support the hypothesis that the A(-656) allele contributes to the development of MDD in women through selective alteration of CREB1 promoter activity by female gonadal steroids in noradrenergic neuronal cells.
|
18317463 |
2009 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This was achieved by replacing the corresponding mouse DNA sequence with a 6-base DNA sequence from the human CREB1 promoter that is associated with the development of MDD in men and women from families identified by probands with recurrent, early-onset MDD (RE-MDD).
|
24006268 |
2014 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese.
|
22480177 |
2012 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the influence of CREB1 polymorphism on cognitive function in patients with MDD.
|
23844928 |
2014 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD.
|
28225778 |
2017 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the potential association of a set of single nucleotide polymorphisms (SNPs) in CREB1 gene and both MD and response, remission and treatment resistance to antidepressants.
|
20643483 |
2011 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we examined the association between CREB1 polymorphisms and anger expression in MDD.
|
17300755 |
2007 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression.
|
12457397 |
2002 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggests that common variations in the CREB1 gene do not appear to increase susceptibility for MDD or related phenotypes.
|
19194961 |
2009 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, polymorphisms in the CREB gene may not be independently associated with MDD risk, but they are likely to confer increased susceptibility by interacting with environmental risk factors in the Chinese population.
|
25755794 |
2015 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The primary aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within two genes implicated in neuroplasticity and inflammatory processes (the mitogen activated protein kinase 1, MAPK1 (rs3810608, rs6928, rs13515 and rs8136867), and the cyclic AMP responsive element binding protein 1, CREB1 (rs889895, rs6740584, rs2551922 and rs2254137)) was associated with antidepressant treatment resistance (according to two different definitions), in 285 Major Depressive Disorder (MDD) patients.
|
23537502 |
2013 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results continue to support sex-specific linkage of the CREB1 region to mood disorders among women from families with RE-MDD.
|
19517574 |
2010 |