Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. 18317451

2008
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction. 17469127

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. 17148458

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells. 17584963

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. 17616684

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. 17606718

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms. 17823925

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. 17551921

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3KAkt. 17898861

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Remnant lipoproteins stimulate proliferation and activate MAPK and Akt signaling pathways via G protein-coupled receptor in PC-3 prostate cancer cells. 17512923

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients. 18087195

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation. 17935714

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation. 17520698

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells. 17914096

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal. 17612563

2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. 16820098

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker LHGDN Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 16543232

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 PosttranslationalModification LHGDN CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. 16114056

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. 17299206

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. 16537497

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. 16951146

2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.400 GeneticVariation LHGDN A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8. 16142341

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Regulated association of protein kinase B/Akt with breast tumor kinase. 15539407

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. 15987444

2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. 15806160

2005